Adaptive Medicine: Early Non-Invasive Diagnosis of Stress-Related Diseases

South Ural State University
Main University Building
76, Prospect Lenina
Tel.: + 7 351 267 96 87

Research Team

Vadim Tseilikman

D.Sc., Professor

Natalia Kundikova

Natalia Kundikova

D.Sc., Professor


The project focuses on the development of the early non-invasive diagnosis of stress-related diseases. The project is multidisciplinary and unites specialists from the fields of medicine, biology, physics, and chemistry. Its primary aim is the early detection of disease-related changes during the latent period, that serve as the disease markers. Hair is chosen as the biological material for the research as a reliable indicator of conformational changes in its proteins, in particular, keratins. One of the primary research methods used will be the Raman scattering method. Due to the dynamic disease development, it is vital to undertake the necessary measurements as frequently as possible. The scientists are planning to research the level of keratin sensitivity to the inducers of oxidative stress.

The research team hopes to determine the number of biophysical properties of hair cells that undergo noticeable changes during the development of stress-related diseases. The researchers expect that as the disease develops, the level of keratin sensitivity to the inducers of oxidative stress will keep increasing. As a result, it will be possible to detect the stress-related disease markers during the latent period. This research can have fundamental implications for the early detection of cancer, cardiovascular diseases and respiratory system diseases.


The research team is planning to patent their method of early non-invasive diagnosis of stress-related diseases, such as PTSD, depression, and cancer and introduce it to medical practice.


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