November 2018

Address: 20A, Chaikovskogo Chelyabinsk, 454 080 Tel.: + 7 919 311 85 99 E-mail: vadimed@yandex.ru Head of the Laboratory Eliyahu Dremencov M.Med.Sc., Ph.D. (Slovak Academy of Sciences) Deputy Head of the Laboratory Vadim Tseilikman D.Sc., Professor (South Ural State University)   Goals The Neurohepatology International Research Laboratory was launched in 2016 under Project 5-100. The laboratory aims to contribute to the research on the link between the liver and regulation of brain activity. The laboratory serves as the starting point of research on the role of liver in the regulation of brain activity under normal circumstances and stress. The Neurohepatology Laboratory will mark a turning point in the development of a new scientific discipline - Neurohepatology, that will become part of neuroscience. About The laboratory conducts empirical research on the role of liver microsomal enzymes in the regulation of neuronal activity by combining electrophysiology, biochemistry, and molecular biology. The laboratory also studies the role of microsomal oxidation in the regulation of brain activity, neurotransmitter exchange, and adrenal gland hormones in animals with low and high levels of microsomal enzymes. The research team relies on the experimental models of anxiety and depressive disorders, including PTSD.   Achievements The ability of liver microsomal enzymes to regulate neuronal activity found for the first time; A new PTSD model developed, in which anxiety and depressive disorders are correlated with adrenal insufficiency and depression of microsomal oxidation. The model is successfully used by Russian and international institutes (Research Institute of Human Morphology (Moscow), National Centre for Genetic Resources of Laboratory Animals (Novosibirsk),  Institute of Molecular Physiology and Genetics, Slovak Academy of Sciences (Slovakia)); The mechanism of treatment-resistant PTSD due to liver damage uncovered for the first time; An empirical PTSD treatment model developed, that focuses on the activation of microsomal enzymes in the liver by hypoxic training; In 2017, research on hydrocorticosteroid state under PTSD, behavioural modification, and organ damage funded by the Russian Science Foundation; the research team is currently working on the project; Federally funded research presently conducted on serotonergic neurons under PTSD. Partners